What do systematic reviews say?

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain