Bacterial collagenolytic protease gene expression · Coronal dentin and enamel caries samples
Genes encoding collagenases and other proteases were overrepresented in dentin caries compared with enamel caries.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Dentinal caries in the primary dentition is associated with about 3.2 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).
1 finding from 1 review
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Stepwise excavation reduced the reported risk of pulp exposure by 69% versus complete caries removal (RR 0.31; ungraded).
1 finding from 1 review
RR 0.31 [0.17, 0.57]
262 participants
GRADE not reported
Arrest of dentine caries · Children with dentine caries in primary and permanent teeth
Professionally applied 38% silver diamine fluoride arrested about two-thirds of active dentine caries surfaces in children (pooled proportion 65.9%, 95% CI 41.2% to 90.7%; 5 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).
1 finding from 1 review
Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in the proportion of children developing caries at 2 to 3 years (RR 1.12, 95% CI 0.60 to 2.09; 2 RCTs; ungraded).
1 finding from 1 review
Dental caries prevalence · European adolescents aged 12 years
Pooled caries prevalence was 0.49 (I² = 99.9%).
1 finding from 1 review
Dental caries prevalence · European adolescents aged 16 years
Pooled caries prevalence was 0.83.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 17 years
Pooled caries prevalence was 0.84.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 18 years
Pooled caries prevalence was 0.74.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 15 years
Pooled caries prevalence was 0.50 (I² = 99.4%).
1 finding from 1 review
Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Enamel caries in the primary dentition is associated with about 1.6 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).
1 finding from 1 review
Pulp exposure during caries removal · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth
Partial caries removal (single stage; residual dentinal caries… probably leads to lower pulp exposure during caries removal compared with complete caries removal (moderate certainty).
1 finding from 1 review
Dental caries prevalence · European adolescents aged 12–19 years
Caries prevalence at the dentine threshold was about 56% (pooled 0.56, 95% CI 0.43 to 0.68; 15 studies; not GRADE-rated).
7 findings from 1 review
Prevalence 0.56 [0.43, 0.68]
15 studies
GRADE not reported
Prevalence 0.49 [0.32, 0.67]
9 studies
GRADE not reported
Prevalence 0.57 [0.32, 0.81]
6 studies
GRADE not reported
Show 4 more findings
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.79 for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
AUC 0.79
7 studies
GRADE not reported
Specificity 0.78 [0.68, 0.85]
7 studies
GRADE not reported
Sensitivity 0.68 [0.54, 0.79]
7 studies
GRADE not reported
Show 1 more finding
DOR 8.01 [4.04, 15.88]
7 studies
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, conventional bitewing radiography (E-speed) pooled sensitivity was 0.48 (95% CI 0.21 to 0.77) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Show 1 more finding
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, visual examination pooled sensitivity was 0.46 (95% CI 0.20 to 0.73) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Sensitivity 0.46 [0.20, 0.73]
8 studies
GRADE not reported
Specificity 0.87 [0.72, 0.95]
8 studies
GRADE not reported
DOR 5.93 [3.11, 11.31]
8 studies
GRADE not reported
Show 1 more finding
AUC 0.79
8 studies
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, fibre-optic transillumination pooled specificity was 0.97 (95% CI 0.89 to 0.994) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Specificity 0.97 [0.89, 0.994]
2 studies
GRADE not reported
DOR 37.77 [13.69, 104.19]
2 studies
GRADE not reported
AUC 0.92
2 studies
GRADE not reported
Show 1 more finding
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.92 for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Show 1 more finding
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, conventional bitewing radiography (D-speed) pooled sensitivity was 0.79 (95% CI 0.41 to 0.96) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Sensitivity 0.79 [0.41, 0.96]
2 studies
GRADE not reported
Specificity 0.75 [0.68, 0.82]
2 studies
GRADE not reported
AUC 0.77
2 studies
GRADE not reported
Show 1 more finding
DOR 11.79 [2.43, 57.24]
2 studies
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, laser fluorescence pen (2190) pooled specificity was 0.77 (95% CI 0.62 to 0.88) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Specificity 0.77 [0.62, 0.88]
4 studies
GRADE not reported
Sensitivity 0.63 [0.37, 0.83]
4 studies
GRADE not reported
DOR 5.85 [1.77, 19.30]
4 studies
GRADE not reported
Show 1 more finding
AUC 0.78
4 studies
GRADE not reported