Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

317 questions · 317 findings · 33 reviews · Anaesthesia

No studies found 49 · 15.5%GRADE not reported 109 · 34.4%Very low 68 · 21.5%Low 69 · 21.8%Moderate 16 · 5%High 6 · 1.9%

Perioperative alcohol cessation intervention vs treatment

In‐hospital and 30‐day mortality · adult surgical patients consuming 3 or more units of alcohol per day

Perioperative alcohol cessation intervention showed no clear difference in in‐hospital and 30‐day mortality compared with treatment (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (Re‐operation for bleeding (reoperation for major bleeding within 30 days (yes/no))) · adults undergoing surgery

It is very uncertain whether the intervention changes adverse events (Re‐operation for bleeding (reoperation for major… (very low certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Blood transfusion · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron probably leads to lower transfusion (measured in participants during or up to 5 days after… compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Number of RBC units transfused per participant (intraoperative to 5 days postoperative) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Mortality (within 30 days after surgery) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in mortality (within 30 days after surgery) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

Bispectral index vs clinical signs

Occurrence of intraoperative awareness Time points of measure after surgery: 2 to 6 hours;12 hours; 1 day; 2 days; 3 days; 14 days; 30 days; or time point was not reported Measurement tools: simple questioning; interviews; or structured questionna... · adults undergoing surgery with general anaesthesia

Bispectral index may leads to lower occurrence of intraoperative awareness Time points of measure after… compared with clinical signs (low certainty).

1 finding from 1 review

Bispectral index vs ETAG

Occurrence of intraoperative awareness Time points of measure after surgery: 2 to 6 hours;12 hours; 1 day; 2 days; 3 days; 14 days; 30 days; or time point was not reported Measurement tools: simple questioning; interviews; or structured questionna... · adults undergoing surgery with general anaesthesia

BIS showed no clear difference in occurrence of intraoperative awareness Time points of measure after… compared with ETAG (low certainty).

1 finding from 1 review