Findings

What do systematic reviews say?

7 questions · 9 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 22.2%Low 2 · 22.2%Moderate 5 · 55.6%High 0 · 0%

Live birth or ongoing pregnancy · women undergoing assisted reproduction

DHEA or testosterone probably leads to higher live birth/ongoing pregnancy rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

2 findings from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 1.81 [1.25, 2.62]
8 studies · 878 participants
Moderate
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 2.6 [1.3, 5.2]
4 studies · 345 participants
Moderate

Miscarriage rate ‐ DHEA · women undergoing assisted reproduction

DHEA or testosterone showed no clear difference in miscarriage rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 0.58 [0.29, 1.17]
8 studies · 950 participants
Moderate

Miscarriage rate ‐ Testosterone · women undergoing assisted reproduction

DHEA or testosterone showed no clear difference in miscarriage rate ‐ Testosterone compared with placebo/no treatment (low certainty).

1 finding from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 2.04 [0.58, 7.13]
4 studies · 345 participants
Low

Clinical pregnancy rate · women undergoing assisted reproduction

DHEA or testosterone probably leads to higher clinical pregnancy rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 1.34 [1.01, 1.76]
12 studies · 1246 participants
Moderate

Clinical pregnancy rate ‐ Testosterone · women undergoing assisted reproduction

DHEA or testosterone probably leads to higher clinical pregnancy rate ‐ Testosterone compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 2.52 [1.36, 4.68]
4 studies · 345 participants
Moderate

Multiple pregnancy · women undergoing assisted reproduction

It is very uncertain whether DHEA or testosterone changes multiple pregnancy ‐ DHEA compared with placebo/no treatment (very low certainty).

2 findings from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 3.23 [0.13, 81.01]
5 studies · 267 participants
Very low
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 3.09 [0.48, 19.98]
3 studies · 292 participants
Very low

DHEAS · Adult female participants with PCOS

1 finding from 1 review

Effect of atorvastatin on testosterone levels 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 125 participants
Low