Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 21 findings · 6 reviews · Gynaecology and Fertility

No studies found 2 · 9.5%GRADE not reported 0 · 0%Very low 6 · 28.6%Low 3 · 14.3%Moderate 10 · 47.6%High 0 · 0%

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Withdrawals due to adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes withdrawal due to adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Specific adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes specific adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Combined oral contraceptive pill vs any other medical treatment

Self‐reported pain (dysmenorrhoea) at the end of treatment (continuous data): dysmenorrhoea at 6 months' · women with endometriosis
2 findings from 1 review

Intervention not reported

Low dose SSRI versus placebo Luteal or continuous administration · women with premenstrual syndrome

The intervention probably leads to higher low dose SSRI versus placebo Luteal or continuous administration (moderate certainty).

1 finding from 1 review

Intervention not reported

Mod dose SSRI versus placebo Luteal or continuous administration · women with premenstrual syndrome

The intervention probably leads to higher mod dose SSRI versus placebo Luteal or continuous administration (moderate certainty).

1 finding from 1 review

Intervention not reported

High dose SSRIs versus placebo Continuous administration · women with premenstrual syndrome

The intervention probably leads to higher high dose SSRIs versus placebo Continuous administration (moderate certainty).

1 finding from 1 review