Cochrane · systematic review · CD001019
Oral contraceptives for pain associated with endometriosis
Brown, J, Crawford, TJ, Datta, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combined oral contraceptive pill compared to placebo or no treatment for pain associated with endometriosis
Population: women with endometriosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Self‐reported pain (dysmenorrhoea) at the end of treatment: dysmenorrhoea VRS Combined oral contraceptive pill vs placebo or no treatment | no estimate extracted | 1 study · 96 participants | Very low Downgraded: imprecision |
Self‐reported pain (dysmenorrhoea) at the end of treatment: dysmenorrhoea VAS Combined oral contraceptive pill vs placebo or no treatment | no estimate extracted | 2 studies · 327 participants | Very low Downgraded: risk of bias, imprecision |
Self‐reported pain: menstrual pain reduction from baseline to end of treatment Combined oral contraceptive pill vs placebo or no treatment | no estimate extracted | 1 study · 169 participants | Very low Downgraded: imprecision |
Combined oral contraceptive pill compared to other medical treatment for pain associated with endometriosis
Population: women with endometriosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Self‐reported pain (dysmenorrhoea) at the end of treatment (continuous data): dysmenorrhoea at 6 months' Combined oral contraceptive pill vs other medical treatment | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias |
Self‐reported pain (dysmenorrhoea) at the end of treatment (continuous data): dysmenorrhoea at 6 months' Combined oral contraceptive pill vs other medical treatment | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias |
Self‐reported pain (dysmenorrhoea) (dichotomous data): reduction of pain to zero at 6 months' Combined oral contraceptive pill vs other medical treatment | RR 0.36 [0.02, 8.43] | 1 study · 50 participants | Very low Downgraded: risk of bias |
Self‐reported pain (dysmenorrhoea) (dichotomous data) ‐ reduction of pain to zero at 6 months' Combined oral contraceptive pill vs other medical treatment | RR 1 [0.93, 1.08] | 1 study · 49 participants | Low Downgraded: risk of bias |