Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 10 reviews · Infectious Diseases

No studies found 1 · 6.7%GRADE not reported 3 · 20%Very low 6 · 40%Low 2 · 13.3%Moderate 3 · 20%High 0 · 0%

Intervention not reported

Discontinuation of study drug due to adverse events · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The intervention probably leads to lower discontinuation of study drug due to adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of study drug due to adverse events · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events the resulted in discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events the resulted in discontinuation of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events that result in the discontinuation of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events that result in the discontinuation of treatment (very low certainty).

1 finding from 1 review

Induction: liposomal amphotericin vs Amphotericin B

Safety outcomes: drug discontinuation · adults with HIV and progressive disseminated histoplasmosis

It is very uncertain whether induction: liposomal amphotericin changes safety outcomes: drug discontinuation compared with amphotericin deoxycholate (very low certainty).

1 finding from 1 review

Linezolid vs no linezolid

Antituberculous treatment discontinuationj · drug‐resistant pulmonary tuberculosis

It is very uncertain whether linezolid changes antituberculous treatment discontinuationj compared with no linezolid (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events leading to treatment discontinuation ( · adults and adolescents with pleural TB

The intervention may leads to higher adverse events leading to treatment discontinuation ( (low certainty).

1 finding from 1 review

Mefloquine vs doxycycline

Discontinuation of treatment due to side effects ( · Non‐immune adults and children travelling to malaria‐endemic settings

Mefloquine showed no clear difference in discontinuations due to adverse effects compared with doxycycline; GRADE not reported.

1 finding from 1 review

Mefloquine vs atovaquone‐proguanil

Discontinuation of medication due to adverse events · non‐immune adults and children travelling to or living in malaria‐endemic settings

Mefloquine led to higher discontinuation of drug due to adverse effects compared with atovaquone‐proguanil; GRADE not reported.

1 finding from 1 review

Fluoroquinolones vs beta‐lactams

Discontinuation of medication due to adverse events · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes adverse events leading to discontinuation of treatment compared with beta‐lactams (very low certainty).

1 finding from 1 review