Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 22 findings · 7 reviews · Urology · Headline outcomes only

No studies found 5 · 22.7%GRADE not reported 0 · 0%Very low 9 · 40.9%Low 7 · 31.8%Moderate 1 · 4.5%High 0 · 0%

Injectional collagenase vs placebo

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Extracorporeal shockwave therapy vs sham

Treatment discontinuation · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether extracorporeal shock wave treatment (ESWT) changes discontinuation from treatment compared with sham (very low certainty).

1 finding from 1 review

Potassium paraaminobenzoate vs placebo

Treatment discontinuation · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes discontinuation from treatment compared with placebo (very low certainty).

1 finding from 1 review

Penile traction therapy vs no treatment (short‐term)

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

It is very uncertain whether penile traction therapy changes discontinuation from treatment compared with no treatment (short‐term) (very low certainty).

1 finding from 1 review

Immune checkpoint inhibitors vs any second‐line chemotherapy

Discontinuation of medication due to adverse events · participants with advanced or metastatic muscle invasive bladder cancer

Immune checkpoint inhibitors may leads to lower discontinuation due to adverse events Range of compared with any second‐line chemotherapy (low certainty).

1 finding from 1 review

Immune checkpoint inhibitors vs any first‐line chemotherapy

Discontinuation of medication due to adverse events · participants with advanced or metastatic muscle invasive bladder cancer

Immune checkpoint inhibitors showed no clear difference in discontinuation due to adverse events Range of compared with any first‐line chemotherapy (low certainty).

1 finding from 1 review

Intervention not reported

Time to initiation of first subsequent therapy This outcome was not reported as a time‐to‐event outcome. Instead, authors of the trials reported the number of participants who received subsequent anticancer therapy after discontinuation of trial t... · people with a confirmed diagnosis of advanced renal cell carcinoma (combined risk groups) without previous systemic anticancer therapy

The intervention may leads to lower time to initiation of first subsequent therapy This outcome was not… (low certainty).

1 finding from 1 review

Intravesically administered BCG combined with IFN‐α vs intravesically administered BCG alone

Discontinuation of therapy due to adverse events ‐ not measured · patients with non‐muscle invasive bladder cancer

The review found no eligible studies for this question.

1 finding from 1 review