What do systematic reviews say?

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  RR 0.93 [0.37, 2.33]
  3 studies · 421 participants
  Very low

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

It is very uncertain whether prothrombin complex concentrate changes number of new occurrences of RBC transfusion compared with any comparator (very low certainty).

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  RR 1.08 [0.82, 1.43]
  2 studies · 376 participants
  Very low

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

It is very uncertain whether prothrombin complex concentrate changes number of complications probably related to the intervention compared with any comparator (very low certainty).

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  RR 0.92 [0.78, 1.09]
  4 studies · 442 participants
  Very low

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 370 participants
  Very low