ACR 50 response of DMARDs naive patients Number of responders · patients with rheumatoid arthritis
MTX combination showed no clear difference in ACR 50 response of DMARDs naive patients Number of responders compared with MTX monotherapy (low certainty).
1 finding from 1 review
ACR 50 response of MTX inadequate responders number of responders · patients with rheumatoid arthritis
MTX combination probably leads to higher ACR 50 response of MTX inadequate responders number of responders compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
ACR 50 response of non‐MTX DMARDs inadequate responders number of responders · patients with rheumatoid arthritis
MTX combination showed no clear difference in ACR 50 response of non‐MTX DMARDs inadequate responders number of… compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
Withdrawal due to lack of efficacy or toxicity of DMARDs naive patients number of withdrawals · patients with rheumatoid arthritis
MTX combination showed no clear difference in withdrawal due to lack of efficacy or toxicity of DMARDs naive… compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
Withdrawal due to lack of efficacy or toxicity of MTX inadequate responders number of withdrawals · patients with rheumatoid arthritis
MTX combination showed no clear difference in withdrawal due to lack of efficacy or toxicity of MTX inadequate… compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
Withdrawal due to lack of efficacy or toxicity of non‐MTX DMARDs inadequate responders number of withdrawals · patients with rheumatoid arthritis
It is very uncertain whether MTX combination changes withdrawal due to lack of efficacy or toxicity of non‐MTX DMARDs… compared with MTX monotherapy (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with rheumatoid arthritis
It is very uncertain whether MTX combination changes withdrawal due to adverse reactions (Pooled across regimens) number… compared with MTX monotherapy (very low certainty).
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · patients with adhesive capsulitis (frozen shoulder)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall pain (change from baseline) · patients with adhesive capsulitis (frozen shoulder)
1 finding from 1 review
Function (change from baseline) Shoulder Disabilty Questionnaire 0‐100 (lower scores = better function) · patients with adhesive capsulitis (frozen shoulder)
1 finding from 1 review
Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)
Combination of manual therapy and exercise probably leads to lower global assessment of treatment success Complete recovery or much… compared with glucocorticoid injection (moderate certainty).
1 finding from 1 review
Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · patients with adhesive capsulitis (frozen shoulder)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · patients with adhesive capsulitis (frozen shoulder)
Combination of manual therapy and exercise probably leads to higher adverse events compared with glucocorticoid injection (moderate certainty).
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · patients with adhesive capsulitis (frozen shoulder)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall pain (change from baseline) · patients with adhesive capsulitis (frozen shoulder)
1 finding from 1 review
Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)f · patients with adhesive capsulitis (frozen shoulder)
1 finding from 1 review
Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder)
1 finding from 1 review
Quality of Life: SF‐36 (physical component) · patients with adhesive capsulitis (frozen shoulder)
1 finding from 1 review
Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)
Combination of manual therapy and exercise following joint distension leads to higher global assessment of treatment success "Success, much improved,… compared with sham ultrasound following joint distension (high certainty).
1 finding from 1 review