Findings

What do systematic reviews say?

9 questions · 11 findings · 2 reviews · Pregnancy and Childbirth · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 18.2%Low 8 · 72.7%Moderate 1 · 9.1%High 0 · 0%

Clindamycin vs placebo

Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection

Clindamycin may leads to higher microbiological cure compared with placebo (low certainty).

1 finding from 1 review

Interventions for treating genital Chlamydia trachomatis infection in pregnancy 2017 · Cochrane Headline outcomes only
RR 4.08 [2.35, 7.08]
1 study · 85 participants
Low

Clindamycin vs erythromycin

Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection

Clindamycin showed no clear difference in microbiological cure compared with erythromycin (low certainty).

1 finding from 1 review

Interventions for treating genital Chlamydia trachomatis infection in pregnancy 2017 · Cochrane Headline outcomes only
RR 1.06 [0.97, 1.15]
2 studies · 173 participants
Low

Clindamycin plus aminoglycoside vs other regimens

Treatment failure ‐ lincosamides versus cephalosporins · women with postpartum endometritis

Clindamycin plus aminoglycoside may leads to lower treatment failure ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

1 finding from 1 review

Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 0.69 [0.49, 0.99]
8 studies · 872 participants
Low

Clindamycin plus aminoglycoside vs other regimens

Treatment failure ‐ lincosamides versus penicillins · women with postpartum endometritis

Clindamycin plus aminoglycoside may leads to lower treatment failure ‐ lincosamides versus penicillins compared with any other regimen (low certainty).

1 finding from 1 review

Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 0.65 [0.46, 0.9]
7 studies · 689 participants
Low

Clindamycin plus aminoglycoside vs other regimens

Severe complication ‐ lincosamides versus cephalosporins · women with postpartum endometritis

It is very uncertain whether clindamycin plus aminoglycoside changes severe complication ‐ lincosamides versus cephalosporins compared with any other regimen (very low certainty).

1 finding from 1 review

Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 2.4 [0.3, 19.19]
4 studies · 476 participants
Very low

Clindamycin plus aminoglycoside vs other regimens

Severe complication ‐ lincosamides versus penicillins · women with postpartum endometritis

Clindamycin plus aminoglycoside showed no clear difference in severe complication ‐ lincosamides versus penicillins compared with any other regimen (low certainty).

1 finding from 1 review

Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 0.33 [0.09, 1.18]
5 studies · 422 participants
Low

Clindamycin plus aminoglycoside vs other regimens

Wound infection · women with postpartum endometritis

Clindamycin plus aminoglycoside may leads to lower wound infection ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

2 findings from 1 review

Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 0.53 [0.3, 0.93]
4 studies · 500 participants
Low
Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 0.46 [0.21, 1]
3 studies · 339 participants
Low

Clindamycin plus aminoglycoside vs other regimens

Allergic reaction · women with postpartum endometritis

Clindamycin plus aminoglycoside showed no clear difference in allergic reaction ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

2 findings from 1 review

Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 1.36 [0.44, 4.21]
6 studies · 680 participants
Low
Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
RR 1 [0.14, 6.96]
2 studies · 247 participants
Very low

Amoxicillin vs clindamycin

Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection

Amoxicillin showed no clear difference in microbiological cure compared with clindamycin (moderate certainty).

1 finding from 1 review

Interventions for treating genital Chlamydia trachomatis infection in pregnancy 2017 · Cochrane Headline outcomes only
RR 0.96 [0.89, 1.04]
1 study · 101 participants
Moderate