All‐cause mortality ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes all‐cause mortality ( compared with control (very low certainty).
1 finding from 1 review
Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review
Amputation · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes incidence of amputation ( compared with control (very low certainty).
1 finding from 1 review
Angiographic analysis · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review
Increase in PFWD (m) ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review
Complications and side effects · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes side effects and complications ( compared with control (very low certainty).
1 finding from 1 review
Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells · patients with venous thromboembolism.
10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · people with critical limb ischaemia
1 finding from 1 review
Reduction in rest pain: rest pain score · people with critical limb ischaemia
1 finding from 1 review
Improvement in lower limb perfusion: ABI · people with critical limb ischaemia
1 finding from 1 review
Improvement in lower limb perfusion: TcO₂ reading in mmHg · people with critical limb ischaemia
1 finding from 1 review
All‐cause mortality during hospital stay · people with critical limb ischaemia
1 finding from 1 review
Rate of amputation · people with critical limb ischaemia
It is very uncertain whether high cell dose changes amputation rate Assessed during in‐patient stay (Losordo 2012) compared with low cell dose (very low certainty).
1 finding from 1 review
Ulcer healing · people with critical limb ischaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Rest‐pain relief · people with critical limb ischaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Improvement in lower limb perfusion: ABI · people with critical limb ischaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Improvement in lower limb perfusion: TcO₂ reading in mmHg · people with critical limb ischaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality during hospital stay · people with critical limb ischaemia
1 finding from 1 review
Rate of amputation · people with critical limb ischaemia
BM‐MNCs showed no clear difference in amputation rate Assessed during in‐patient stay compared with mPBSCs (low certainty).
1 finding from 1 review