Findings

What do systematic reviews say?

13 questions · 14 findings · 2 reviews · Pain, Palliative and Supportive Care · Headline outcomes only

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No studies found 4 · 28.6%GRADE not reported 0 · 0%Very low 2 · 14.3%Low 2 · 14.3%Moderate 6 · 42.9%High 0 · 0%

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Substantial benefit · adults with postherpetic neuralgia

The review found no eligible studies for this question.

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

PGICvery much improved, week 8 and week 12 · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Moderate benefit · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Patient Global Impression of Change much or very much improved · adults with postherpetic neuralgia

2 findings from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 571 participants
Moderate
Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 571 participants
Moderate

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Lack of efficacy withdrawal · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 2073 participants
Moderate

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Withdrawals due to adverse events · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2487 participants
Moderate

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Serious adverse events · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1993 participants
Moderate

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Death · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2487 participants
Very low

Summary of findings table ‐ Topical capsaicin vs placebo

Pruritus · patients with chronic kidney disease (CKD) pruritus

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
Low

Summary of findings table ‐ Topical capsaicin vs placebo

Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Topical capsaicin vs placebo

Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Topical capsaicin vs placebo

Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Topical capsaicin vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Topical capsaicin may leads to higher risk for at least one adverse event per patient compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
RR 3.69 [1.17, 11.67]
3 studies · 116 participants
Low