Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

695 questions · 728 findings · 63 reviews · Headline outcomes only

No studies found 219 · 30.1%GRADE not reported 55 · 7.6%Very low 194 · 26.6%Low 136 · 18.7%Moderate 90 · 12.4%High 34 · 4.7%

CERA vs other ESA

Final Hb · patients with the anaemia of end‐stage kidney disease undergoing dialysis
3 findings from 1 review

CERA vs other ESA

All‐cause mortality: CERA every 2 weeks versus rHuEPO · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in all‐cause mortality: CERA every 2 weeks versus rHuEPO compared with other ESA (moderate certainty).

1 finding from 1 review

CERA vs other ESA

Transfusions: CERA every 2 weeks versus rHuEPO · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in transfusions: CERA every 2 weeks versus rHuEPO compared with other ESA (moderate certainty).

1 finding from 1 review

CERA vs other ESA

Adverse events: hypertension · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in numbers of adverse events due to hypertension: CERA every 2 weeks… compared with other ESA (high certainty).

1 finding from 1 review

CERA vs other ESA

Numbers of adverse events due to access thrombosis · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in numbers of adverse events due to access thrombosis: CERA every 2… compared with other ESA (moderate certainty).

1 finding from 1 review

'Driving whilst intoxicated' programme + incarceration vs incarceration alone

Reconviction (for drink‐driving) Assessed by: Cox regression of re‐arrest rates over 24 months Timing of assessment: 24 months · adults with antisocial personality disorder

It is very uncertain whether 'Driving whilst intoxicated' programme + incarceration changes reconviction (for drink‐driving) Assessed by: Cox regression of… compared with incarceration alone (very low certainty).

1 finding from 1 review

Intervention not reported

Reulceration · people with healed venous leg ulcers

The intervention showed no clear difference in reulceration (low certainty).

1 finding from 1 review