Findings

What do systematic reviews say?

28 questions · 30 findings · 10 reviews · Tobacco Addiction

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No studies found 1 · 3.3%GRADE not reported 0 · 0%Very low 6 · 20%Low 15 · 50%Moderate 4 · 13.3%High 4 · 13.3%

Bupropion vs control

Bupropion versus placebo All biochemically validated · smokers with current depression

Bupropion showed no clear difference in bupropion versus placebo All biochemically validated compared with control (low certainty).

1 finding from 1 review

Smoking cessation interventions for smokers with current or past depression 2013 · Cochrane Headline outcomes only
RR 1.37 [0.83, 2.27]
5 studies · 410 participants
Low

Bupropion vs control

Bupropion versus placebo Biochemical validation (majority) and self report · patients with smokers with past depression

Bupropion may leads to higher bupropion versus placebo Biochemical validation (majority) and self… compared with control (low certainty).

1 finding from 1 review

Smoking cessation interventions for smokers with current or past depression 2013 · Cochrane Headline outcomes only
RR 2.04 [1.31, 3.18]
4 studies · 404 participants
Low

Bupropion vs placebo or no pharmacological treatment

Smoking cessation · people who smoke

Bupropion leads to higher smoking cessation (at least six months of compared with placebo/no pharmacological treatment (high certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.6 [1.49, 1.72]
50 studies · 18577 participants
High

Bupropion vs placebo or no pharmacological treatment

Serious adverse events · people who smoke

Bupropion showed no clear difference in serious adverse events compared with placebo/no pharmacological treatment (moderate certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.16 [0.9, 1.48]
23 studies · 10958 participants
Moderate

Bupropion vs placebo or no pharmacological treatment

Dropouts due to treatment · people who smoke

Bupropion leads to higher dropouts due to treatment compared with placebo/no pharmacological treatment (high certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.44 [1.27, 1.65]
25 studies · 12346 participants
High

Bupropion vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Bupropion showed no clear difference in biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
RR 0.74 [0.21, 2.64]
2 studies · 76 participants
Low

Bupropion vs control

Mean birthweight · Pregnant women who smoke

Bupropion showed no clear difference in mean birthweight (g) compared with control (low certainty).

1 finding from 1 review

Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
MD 122.64
2 studies · 68 participants
Low

Bupropion vs control

Miscarriage and spontaneous abortion · Pregnant women who smoke

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bupropion plus varenicline vs varenicline

Smoking cessation · people who smoke

Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.21 [0.95, 1.55]
3 studies · 1057 participants
Moderate

Bupropion plus varenicline vs varenicline

Serious adverse events · people who smoke

Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.23 [0.63, 2.42]
5 studies · 1268 participants
Low

Bupropion plus varenicline vs varenicline

Dropouts due to treatment · people who smoke

Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.8 [0.45, 1.45]
4 studies · 1230 participants
Low

Bupropion plus nicotine replacement therapy (NRT) vs NRT

Smoking cessation · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.17 [0.95, 1.44]
15 studies · 4117 participants
Low

Bupropion plus nicotine replacement therapy (NRT) vs NRT

Serious adverse events · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in serious adverse events compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.52 [0.26, 8.89]
4 studies · 657 participants
Low

Bupropion plus nicotine replacement therapy (NRT) vs NRT

Dropouts due to treatment · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in dropouts due to treatment compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.67 [0.95, 2.92]
3 studies · 737 participants
Low

Intervention not reported

Bupropion therapy plus behavioral intervention vs behavioral intervention alone (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral intervention vs behavioral… (very low certainty).

1 finding from 1 review

Interventions for waterpipe smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.77 [0.42, 1.41]
121 participants
Very low

Intervention not reported

Bupropion therapy plus behavioral support versus self‐help (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral support versus self‐help… (very low certainty).

1 finding from 1 review

Interventions for waterpipe smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.94 [0.94, 4]
86 participants
Very low

Intervention not reported

Bupropion · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in bupropion (moderate certainty).

1 finding from 1 review

Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta‐analyses 2023 · Cochrane Headline outcomes only
OR 1.35 [0.97, 1.92]
22 studies · 7231 participants
Moderate

Intervention not reported

Bupropion · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention leads to higher bupropion (high certainty).

1 finding from 1 review

Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta‐analyses 2023 · Cochrane Headline outcomes only
OR 1.43 [1.26, 1.62]
71 studies · 14759 participants
High

Intervention not reported

Bupropion versus placebo Smoking cessation · people who have quit smoking using a cessation intervention

The intervention showed no clear difference in bupropion versus placebo Smoking cessation (moderate certainty).

1 finding from 1 review

Relapse prevention interventions for smoking cessation 2019 · Cochrane Headline outcomes only
RR 1.15 [0.98, 1.35]
6 studies · 1697 participants
Moderate

Intervention not reported

Combination NRT & bupropion versus placebo Smoking cessation · people who have quit smoking using a cessation intervention

The intervention showed no clear difference in combination NRT & bupropion versus placebo Smoking cessation (low certainty).

1 finding from 1 review

Relapse prevention interventions for smoking cessation 2019 · Cochrane Headline outcomes only
RR 1.18 [0.75, 1.87]
2 studies · 243 participants
Low