Bisphosphonates showed no clear difference in proportion of participants with pain response compared with placebo/no treatment (low certainty).
Bisphosphonates probably leads to lower skeletal‐related events: any, composite outcome compared with placebo/no treatment (moderate certainty).
Bisphosphonates showed no clear difference in mortality compared with placebo/no treatment (moderate certainty).
The review found no eligible studies for this question.
Bisphosphonates showed no clear difference in adverse events: nausea compared with placebo/no treatment (moderate certainty).
Bisphosphonates probably leads to higher adverse events: renal compared with placebo/no treatment (moderate certainty).
It is very uncertain whether bisphosphonates changes adverse events: osteonecrosis of the jaw compared with placebo/no treatment (very low certainty).
Bisphosphonates probably leads to lower proportion of participants with disease progression compared with placebo/no treatment (moderate certainty).