Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 5 reviews

No studies found 13 · 39.4%GRADE not reported 4 · 12.1%Very low 8 · 24.2%Low 5 · 15.2%Moderate 1 · 3%High 2 · 6.1%

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ lorazepam + risperidone vs lorazepam… compared with same enzodiazepines (low certainty).

1 finding from 1 review

Benzodiazepines (lorazepam) vs Oxazepam

Catatonia: clinically important change in catatonia symptoms (improved at least 50% on the VAS) · catatonia in people with schizophrenia or SMI

It is very uncertain whether lorazepam changes catatonia: clinically important change in catatonia symptoms… compared with oxazepam (very low certainty).

1 finding from 1 review