Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 2 reviews

No studies found 10 · 47.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 8 · 38.1%Moderate 3 · 14.3%High 0 · 0%

Benzbromarone vs probenecid

Withdrawals due to adverse events · people with chronic gout

Benzbromarone may leads to lower withdrawal due to adverse events compared with probenecid (low certainty).

1 finding from 1 review

Benzbromarone vs allopurinol

Serum urate normalisation ‐ not reported · people with chronic gout

Benzbromarone showed no clear difference in serum urate normalisation compared with allopurinol (moderate certainty).

1 finding from 1 review

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Benzbromarone vs probenecid

Acute gout attacks · people with chronic gout

Benzbromarone showed no clear difference in acute gout attacks compared with probenecid (low certainty).

1 finding from 1 review

Benzbromarone vs probenecid

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) · people with chronic gout

Benzbromarone probably leads to higher serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) compared with probenecid (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with benzbromarone (low certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Proportion achieving target serum urate · people with chronic gout

Allopurinol showed no clear difference in proportion achieving target serum urate compared with benzbromarone (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with benzbromarone (low certainty).

1 finding from 1 review