Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Barbiturate treatment vs placebo or no treatment

Death or major neurodevelopmental disability · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes death or major neurodevelopmental disability compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.33 [0.14, 0.78]
1 study · 31 participants
Very low

Barbiturate treatment vs placebo or no treatment

Death · infants with perinatal asphyxia

Barbiturate treatment showed no clear difference in death compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.88 [0.55, 1.42]
8 studies · 429 participants
Low

Barbiturate treatment vs placebo or no treatment

Major neurodevelopmental disability at childhood · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes major neurodevelopmental disability compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.24 [0.06, 0.92]
1 study · 31 participants
Very low

Barbiturate treatment vs placebo or no treatment

Cerebral palsy · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes cerebral palsy compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.58 [0.19, 1.7]
2 studies · 69 participants
Very low

Barbiturate treatment vs placebo or no treatment

Developmental delay at ≥ 18 months · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes developmental delay compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.54 [0.24, 1.19]
2 studies · 63 participants
Very low

Barbiturate treatment vs placebo or no treatment

Seizures · infants with perinatal asphyxia

Barbiturate treatment may leads to lower seizures (clinical or electrographic) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.62 [0.48, 0.81]
6 studies · 319 participants
Low

Barbiturate treatment vs placebo or no treatment

Abnormal neurologic exam at discharge · infants with perinatal asphyxia

Barbiturate treatment showed no clear difference in abnormal neurologic exam at discharge compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.85 [0.67, 1.08]
4 studies · 245 participants
Low