Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 32 findings · 7 reviews · Skin · Headline outcomes only

No studies found 18 · 56.3%GRADE not reported 0 · 0%Very low 3 · 9.4%Low 7 · 21.9%Moderate 3 · 9.4%High 1 · 3.1%

Skin protection education vs no intervention or minimal intervention

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

It is very uncertain whether skin protection education changes the proportion of participants developing any signs and symptoms of… compared with no or minimal intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Transepidermal water loss (TEWL) Measured using temperature‐adjusted g/m²/h with the Tewameter TM 300 (Courage + Khazaka, Cologne, Germany) Hahnel 2017: measured at 56 ± 4 days Shishido 2017: measured 15 minutes after wiping the skin with a dry to... · people 60 years of age and older
1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Primary: adverse events ‐ any adverse event treatment‐related (application site pruritus) · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ any adverse event treatment‐related… compared with vehicle foam (moderate certainty).

1 finding from 1 review

Barrier creams vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Barrier creams showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Moisturisers vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Moisturisers showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Barrier creams and moisturisers vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Barrier creams and moisturisers showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Clearance, as assessed by a clinician at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol probably leads to higher clearance, as assessed by a clinician at any compared with placebo (moderate certainty).

1 finding from 1 review

Topical timolol vs placebo

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Topical timolol may leads to higher other measures of resolution, as assessed by a clinician, at any compared with placebo (low certainty).

1 finding from 1 review

Oral propranolol vs topical timolol

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in other measures of resolution, as assessed by a clinician, at any compared with topical timolol (low certainty).

1 finding from 1 review

Oral propranolol vs placebo

A subjective measure of improvement, as assessed by the parent or child, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Oral propranolol vs placebo

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in other measures of resolution, as assessed by a clinician, at any compared with placebo (moderate certainty).

1 finding from 1 review