Any growth factor may leads to higher complete wound closure compared with placebo or no growth factor (low certainty).
It is very uncertain whether any growth factor changes lower limb amputation (minimum of one toe) compared with placebo or no growth factor (very low certainty).
Any growth factor showed no clear difference in adverse events (non‐serious and serious) compared with placebo or no growth factor (low certainty).
Growth factors may leads to lower any limb amputation ( compared with placebo or no therapy (low certainty).
Growth factors showed no clear difference in any adverse event ( compared with placebo or no therapy (moderate certainty).
Anti‐VEGF probably leads to lower adverse outcomes at any time point compared with steroid (moderate certainty).
It is very uncertain whether anti‐VEGF changes adverse outcomes at any time point compared with sham (very low certainty).
It is very uncertain whether anti‐VEGF changes adverse outcomes at any time point compared with laser (very low certainty).
EGFR tyrosine kinase inhibitor (TKI) plus chemotherapy showed no clear difference in toxicity: cardiac toxicity (any grade) compared with chemotherapy alone (low certainty).