Mean change in pain from baseline (0‐ to 10‐point scale, 0 is no pain) at 8–16 weeks · predominantly knee osteoarthritis
Antidepressant showed no clear difference in mean change in pain from baseline (0‐ to 10‐point scale, 0 is no… compared with placebo (high certainty).
1 finding from 1 review
At least 50% reduction in pain · predominantly knee osteoarthritis
Antidepressant leads to higher responder rate: ≥ 50% reduction in 24‐hour mean pain compared with placebo (high certainty).
1 finding from 1 review
Physical function · predominantly knee osteoarthritis
Antidepressant showed no clear difference in mean change in physical function from baseline (0–100 WOMAC Total… compared with placebo (high certainty).
1 finding from 1 review
Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis
Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).
1 finding from 1 review
Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis
Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).
1 finding from 1 review
Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis
Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).
1 finding from 1 review
Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis
Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).
1 finding from 1 review
Pain < 1 week VAS scale 0 to 100 mm · patients with pain management in rheumatoid arthritis
1 finding from 1 review
Pain 1 to 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis
1 finding from 1 review
Pain > 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis
1 finding from 1 review
Functional Status Health Assessment Questionnaire (HAQ) scale 0 to 3 · patients with pain management in rheumatoid arthritis
1 finding from 1 review
Withdrawals due to adverse events · patients with pain management in rheumatoid arthritis
It is very uncertain whether tricyclic antidepressant changes number of Withdrawals due to Adverse Events patient interview compared with control (very low certainty).
1 finding from 1 review
Total number of adverse events patient interview · patients with pain management in rheumatoid arthritis
It is very uncertain whether tricyclic antidepressant changes total number of adverse events patient interview compared with control (very low certainty).
1 finding from 1 review