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What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 51 findings · 5 reviews · Stroke · Headline outcomes only

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No studies found 11 · 21.6%GRADE not reported 0 · 0%Very low 12 · 23.5%Low 13 · 25.5%Moderate 10 · 19.6%High 5 · 9.8%

Anticoagulant vs control

Dead or dependent · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant showed no clear difference in dead or dependent at end of compared with control (high certainty).

1 finding from 1 review

Anticoagulant vs control

Death during study period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant showed no clear difference in death from all causes during treatment period compared with control (low certainty).

1 finding from 1 review

Anticoagulant vs control

Deep vein thrombosis · acute presumed ischaemic stroke

It is very uncertain whether summary of findings table ‐ Anticoagulant changes deep vein thrombosis during treatment period compared with control (very low certainty).

1 finding from 1 review

Anticoagulant vs control

Recurrent ischaemic or unknown stroke during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to lower recurrent ischaemic or unknown stroke during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulant vs control

Symptomatic intracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher symptomatic intracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulant vs control

Symptomatic PE · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant leads to lower symptomatic pulmonary embolism during treatment period compared with control (high certainty).

1 finding from 1 review

Anticoagulant vs control

Major extracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher major extracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes death or dependence (mRS 4–6) compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Intracerebral haemorrhage expansion by 24 hours · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes intracerebral haemorrhage expansion by 24 hours compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes all serious adverse events compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Death from any cause · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes death from any cause compared with fresh frozen plasma (very low certainty).

1 finding from 1 review