Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

162 questions · 163 findings · 18 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

No studies found 47 · 28.8%GRADE not reported 0 · 0%Very low 28 · 17.2%Low 45 · 27.6%Moderate 35 · 21.5%High 8 · 4.9%

Summary of findings: Inhaled antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics changes need for additional IV or oral antibiotics compared with IV antibiotics (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Adverse events (moderate) · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes adverse events moderate adverse events experienced during and after… compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Microbiology Emergence of resistant organisms · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes microbiology Emergence of resistant organisms compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Quality of life: number of participants achieving MCID · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

Summary of findings: Inhaled antibiotics plus IV antibiotics showed no clear difference in quality of life: number of participants achieving MCID compared with IV antibiotics only (low certainty).

1 finding from 1 review