Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

138 questions · 140 findings · 14 reviews · Kidney and Transplant

No studies found 22 · 15.7%GRADE not reported 0 · 0%Very low 46 · 32.9%Low 47 · 33.6%Moderate 25 · 17.9%High 0 · 0%

Antibiotic 1 vs antibiotic 2

Recurrence of symptomatic UTI: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in recurrence of symptomatic UTI: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (moderate certainty).

2 findings from 1 review

Antibiotic 1 vs antibiotic 2

Microbial resistance to prophylactic drugs: nitrofurantoin (1) versus cotrimoxazole (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 probably leads to lower microbial resistance to prophylactic drugs: nitrofurantoin (1)… compared with antibiotic 2 (moderate certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in adverse events: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: nitrofurantoin (1) versus trimethoprim (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 may leads to higher adverse events: nitrofurantoin (1) versus trimethoprim (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Recurrence of symptomatic UTI in children · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in recurrence of symptomatic UTI: cotrimoxazole (1) versus cefadroxil (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

New renal parenchymal defects (scars and thinning) on IVP: unit of analysis (children) at 4 to 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

Surgical reimplantation of ureters plus antibiotics showed no clear difference in new renal parenchymal defects (scars and thinning) on IVP: unit of… compared with antibiotics alone (moderate certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

Correction of VUR: unit of analysis (children) after 3 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

It is very uncertain whether surgical reimplantation of ureters plus antibiotics changes correction of VUR: unit of analysis (children) after 3 years:… compared with antibiotics alone (very low certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

Febrile UTI by 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

Surgical reimplantation of ureters plus antibiotics probably leads to lower febrile UTI by 5 years: surgical correction + antibiotics versus… compared with antibiotics alone (moderate certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Development of antibiotic resistance · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Number of participants with symptomatic UTI · primary VUR

Antibiotic prophylaxis showed no clear difference in symptomatic UTI by 1 to 2 years: antibiotics versus no prophylaxis compared with surveillance or no treatment (low certainty).

2 findings from 1 review