Findings

What do systematic reviews say?

26 questions · 26 findings · 3 reviews

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No studies found 3 · 11.5%GRADE not reported 0 · 0%Very low 11 · 42.3%Low 7 · 26.9%Moderate 4 · 15.4%High 1 · 3.8%

Amiodarone vs placebo or no treatment

Sudden cardiac death · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone may leads to lower sudden cardiac death compared with placebo or no treatment (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.76 [0.66, 0.88]
17 studies · 8383 participants
Low

Amiodarone vs other antiarrhythmics

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

Amiodarone showed no clear difference in all‐cause mortality compared with other antiarrhythmics (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 1.03 [0.75, 1.42]
5 studies · 898 participants
Low

Amiodarone vs beta‐blocker

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with beta blockers (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.84 [0.55, 1.27]
1 study · 189 participants
Very low

Amiodarone vs beta‐blocker

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with beta blockers (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.96 [0.7, 1.32]
1 study · 189 participants
Very low

Amiodarone vs sotalol

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with sotalol (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 2.87 [0.32, 25.55]
1 study · 45 participants
Very low

Amiodarone vs sotalol

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with sotalol (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 1.08 [0.41, 2.83]
2 studies · 104 participants
Very low

Amiodarone vs placebo or no treatment

All‐cause mortality · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.88 [0.78, 1]
17 studies · 8383 participants
Low

Amiodarone vs beta‐blocker

Sudden cardiac death · beta blockers

Amiodarone showed no clear difference in sudden cardiac death compared with beta blockers (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.37 [0.11, 1.22]
2 studies · 342 participants
Low

Amiodarone vs beta‐blocker

All‐cause mortality · beta blockers

Amiodarone may leads to lower all‐cause mortality compared with beta blockers (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.27 [0.1, 0.75]
2 studies · 342 participants
Low

Amiodarone vs other antiarrhythmics

Sudden cardiac death · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone showed no clear difference in sudden cardiac death compared with other antiarrhythmics (moderate certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.44 [0.19, 1]
3 studies · 540 participants
Moderate

Amiodarone vs other antiarrhythmics

All‐cause mortality · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone probably leads to lower all‐cause mortality compared with other antiarrhythmics (moderate certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.37 [0.18, 0.76]
3 studies · 540 participants
Moderate

Amiodarone vs placebo or no treatment

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 4.32 [0.87, 21.49]
2 studies · 440 participants
Very low

Amiodarone vs placebo or no treatment

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 3.05 [1.33, 7.01]
2 studies · 440 participants
Very low

Amiodarone vs other antiarrhythmics

Sudden cardiac death · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes sudden cardiac death compared with other antiarrhythmics (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 1.4 [0.56, 3.52]
4 studies · 839 participants
Very low

Amiodarone vs placebo or no treatment

All‐cause mortality · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.66 [0.55, 4.99]
2 studies · 444 participants
Moderate

Amiodarone vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone may leads to higher withdrawals due to adverse effects compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 6.7 [1.91, 23.45]
4 studies · 319 participants
Low

Amiodarone vs placebo or no treatment

Proarrhythmia · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone showed no clear difference in proarrhythmia compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 2.22 [0.71, 6.96]
4 studies · 673 participants
Moderate

Amiodarone vs placebo or no treatment

Stroke · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone showed no clear difference in stroke compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.15 [0.3, 4.39]
1 study · 399 participants
Low

Amiodarone vs placebo or no treatment

Recurrence of atrial fibrillation · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone leads to lower recurrence of atrial fibrillation compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 0.52 [0.46, 0.58]
6 studies · 812 participants
High

Lidocaine vs amiodarone

All‐cause mortality · patients with myocardial infarction

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic lidocaine for myocardial infarction 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found