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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 6 findings · 2 reviews · Drugs and Alcohol

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 3 · 50%High 0 · 0%

Amantadine vs placebo

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in adverse events as N of participants with at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Amantadine vs placebo

Abstinence · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in abstinence (objective) N of subjects abstinent at the end of the study compared with placebo (low certainty).

2 findings from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: clonidine versus clonidine plus amantadine, inpatient setting · management of opium withdrawal

It is very uncertain whether pharmacological detoxification treatment changes completion of treatment: clonidine versus clonidine plus amantadine,… compared with other pharmacological detoxification treatment (very low certainty).

1 finding from 1 review