Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

86 questions · 97 findings · 13 reviews · Infectious Diseases · Headline outcomes only

No studies found 4 · 4.1%GRADE not reported 9 · 9.3%Very low 13 · 13.4%Low 31 · 32%Moderate 34 · 35.1%High 6 · 6.2%

Multiple doses of deworming drugs vs placebo

Death (between ages 1 and 6 years) · public health programmes to regularly treat all children aged 16 years or less

Multiple doses of deworming drugs showed no clear difference in mortality (between ages 1 and 6 years) compared with placebo (low certainty).

1 finding from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Cumulative cases of typhoid fever at 2 years · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower cumulative cases of typhoid fever at 2 years compared with control (moderate certainty).

2 findings from 1 review

Ty21a vaccine (three doses) vs control

Cumulative cases of typhoid fever at 2.5 to 3 years · adults and children aged 5 years of age and older

Ty21a vaccine (three doses) probably leads to lower cumulative cases of typhoid fever at 2.5 to 3 years compared with control (moderate certainty).

1 finding from 1 review

Vi polysaccharide vaccine (1 dose) vs control

Cumulative cases of typhoid fever at 2.5 to 3 years · adults and children of 2 years of age and older

Vi polysaccharide vaccine (1 dose) may leads to lower cumulative cases of typhoid fever at 2.5 to 3 years compared with control (low certainty).

1 finding from 1 review

Intervention not reported

Child death by two years of age · HIV‐positive women during pregnancy and immediate postpartum period

The intervention showed no clear difference in child death by two years of age (low certainty).

1 finding from 1 review