Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Surgical anchorage (mini-screw or mid-palatal implant) vs Conventional anchorage (headgear, transpalatal/palatal arch, etc.)

Success or failure of the anchorage device · Patients of any age undergoing orthodontic treatment with fixed appliances and requiring anchorage (adolescents to adults up to 48-54 years)
1 finding from 1 review

Fluoride varnish applied before 4 years of age vs No fluoride varnish application

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Fluoride varnish applied before 4 years of age may leads to higher fluorosis (percentage prevalence in permanent teeth) compared with no fluoride varnish application (low certainty).

1 finding from 1 review

Fluoride varnish applied before 4 years of age vs Non-fluoride (placebo) varnish

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Fluoride varnish applied before 4 years of age (biannual) showed no clear difference in fluorosis (percentage prevalence in permanent teeth) compared with placebo varnish (low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Patient or population: HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)Settings: Thailand and CambodiaIntervention: IMMEDIATE initiation of cARTComparison: DEFERRED initiation of cART · HIV‐positive, treatment‐naive children aged one to 12 years old

The review found no eligible studies for this question.

1 finding from 1 review

Engagement of community leaders vs usual care

Proportion of children who received DTP3 or Penta 3 by 1 year of age · children under 5 years of age

Engagement of community leaders probably leads to higher proportion of children who received DTP3 or Penta 3 by 1 year of age compared with routine care (moderate certainty).

1 finding from 1 review

Monetary incentives vs usual care

Proportion of children under 5 years of age fully immunised with all scheduled vaccines · children under 5 years of age

It is very uncertain whether monetary incentives changes proportion of children under 5 years of age fully immunised with all… compared with routine care (very low certainty).

1 finding from 1 review

Digital register vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

Digital register showed no clear difference in proportion of children who received all recommended vaccines by 2… compared with routine care (low certainty).

1 finding from 1 review

Phone call/SMS with/without combination with monetary incentives vs usual care

Proportion of children who received all recommended vaccines by 2 years of age (phone call/SMS only) · children under 5 years of age

Phone call/SMS with/without combination with monetary incentives showed no clear difference in proportion of children who received all recommended vaccines by 2… compared with routine care (low certainty).

1 finding from 1 review

Phone call/SMS with/without combination with monetary incentives vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

Phone call/SMS with/without combination with monetary incentives may leads to higher proportion of children who received all recommended vaccines by 2… compared with routine care (low certainty).

1 finding from 1 review

Training of health providers vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

It is very uncertain whether training of health providers changes proportion of children who received all recommended vaccines by 2… compared with routine care (very low certainty).

1 finding from 1 review

Home visit vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

It is very uncertain whether home visit changes proportion of children who received all recommended vaccines by 2… compared with routine care (very low certainty).

1 finding from 1 review