Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 22 findings · 9 reviews

No studies found 3 · 13.6%GRADE not reported 5 · 22.7%Very low 3 · 13.6%Low 3 · 13.6%Moderate 7 · 31.8%High 1 · 4.5%

Additional support vs usual care

Satisfaction with pregnancy care Pregnancy care rated as "very helpful" · women at increased risk of low birthweight babies (maternal outcomes)

Additional support probably leads to higher satisfaction with pregnancy care Pregnancy care rated as "very… compared with usual care during pregnancy (moderate certainty).

1 finding from 1 review

Additional support vs usual care

Death of a baby (stillbirth or neonatal death) report of perinatal death · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in stillbirth/neonatal death compared with usual care during pregnancy (low certainty).

1 finding from 1 review

Additional support vs usual care

Number of antenatal hospital admissions · women at increased risk of low birthweight babies (maternal outcomes)

Additional support probably leads to lower antenatal hospital admissions Number of admissions per woman compared with usual care during pregnancy (moderate certainty).

2 findings from 1 review

Additional support vs usual care

Postnatal depression · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in postnatal depression Self‐reported compared with usual care during pregnancy (low certainty).

2 findings from 1 review

Comprehensive oral health intervention (oral health education plus additional support: motivational interviewing, toothbrush/toothpaste provision, community engagement, and/or fluoride varnish/sealant application) delivered by non-dental health workers vs control (no intervention/usual care/isotonic exercise)

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers

Comprehensive interventions produced a small, statistically significant reduction in surface-level caries (dmfs SMD -0.14, 95% CI -0.26 to -0.02; 10 studies; not GRADE-rated).

1 finding from 1 review

Comprehensive oral health intervention (oral health education plus additional support: motivational interviewing, toothbrush/toothpaste provision, community engagement, and/or fluoride varnish/sealant application) delivered by non-dental health workers vs control (no intervention/usual care/isotonic exercise)

Caries experience · Children (mean age newborn to ~5.2 years) and their parents/carers

Comprehensive interventions produced a statistically significant reduction in tooth-level caries (dmft SMD -0.47, 95% CI -0.84 to -0.10; 4 studies; not GRADE-rated), though heterogeneity was very high.

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

Satisfaction and acceptability of treatment (medium term) ‐ leaving the study early · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early Endpoint data… compared with supportive therapy (very low certainty).

1 finding from 1 review

Maternal advice and support (feeding techniques/breastfeeding positions) vs Usual care (no additional advice/support)

Outcome not reported · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

The review found no eligible studies for this question.

1 finding from 1 review

Higher‐dose anticoagulants vs lower‐dose anticoagulants

Necessity for additional respiratory support · people hospitalised with COVID‐19

It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs supplemental oxygen

Treatment failure (death or use of additional ventilatory support) · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether CPAP changes treatment failure (death or use of additional ventilatory support) compared with supplemental oxygen (very low certainty).

1 finding from 1 review