Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

203 questions · 203 findings · 10 reviews · Gut · Headline outcomes only

No studies found 84 · 41.4%GRADE not reported 7 · 3.4%Very low 64 · 31.5%Low 38 · 18.7%Moderate 9 · 4.4%High 1 · 0.5%

Intervention not reported

H. pylori eradication therapy versus no active treatment · people with Helicobacter pylori‐positive peptic ulcer

The intervention may leads to lower H. pylori eradication therapy versus no active treatment (low certainty).

1 finding from 1 review

Intervention not reported

H. pylori eradication therapy versus no active treatment · prevention of recurrence in people with Helicobacter pylori‐positive peptic ulcer

It is very uncertain whether the intervention changes H. pylori eradication therapy versus no active treatment (very low certainty).

1 finding from 1 review

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

Clinical relapse · people with inflammatory bowel disease

High‐treatment‐dose vitamin D (greater than 1000 IU/day) showed no clear difference in clinical relapse at end of study (52 weeks) compared with low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day) (low certainty).

1 finding from 1 review

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

Withdrawals due to adverse events · people with inflammatory bowel disease

It is very uncertain whether high‐treatment‐dose vitamin D (greater than 1000 IU/day) changes withdrawals due to adverse events compared with low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day) (very low certainty).

1 finding from 1 review

Any‐treatment‐dose vitamin D (greater than 400 IU/day) vs supplemental‐dose vitamin D (less than 400 IU/day)

Withdrawals due to adverse events · people with inflammatory bowel disease

It is very uncertain whether any‐treatment‐dose vitamin D (greater than 400 IU/day) changes withdrawals due to adverse events compared with supplemental‐dose vitamin D (less than 400 IU/day) (very low certainty).

1 finding from 1 review

Intervention not reported

Colonic transit rate (geometric centre of radioactive substance). Unit indicates position along with intestinal tract. Scale from: 1 (small intestine) to 5 (rectosigmoid area). · children with chronic constipation
1 finding from 1 review

Three infusions of natalizumab (300 mg) and two infusions of infliximab (5 mg/kg) vs placebo and two infusions of infliximab

Failure to induce clinical remission at end of study · Participants with active Crohn's disease despite current treatment with infliximab

Three infusions of natalizumab (300 mg) and two infusions of… showed no clear difference in failure to induce clinical remission at week 10 compared with placebo and two infusions of infliximab (moderate certainty).

1 finding from 1 review