Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 33 findings · 4 reviews · Bone, Joint and Muscle Trauma

No studies found 5 · 15.2%GRADE not reported 2 · 6.1%Very low 16 · 48.5%Low 8 · 24.2%Moderate 2 · 6.1%High 0 · 0%

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Active finger range of motion · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Active exercise regimen vs an immobilisation regimen following surgery

Range of movement · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether active exercise regimen changes range of movement compared with an immobilisation regimen following surgery (very low certainty).

2 findings from 1 review

Active exercise regimen vs an immobilisation regimen following surgery

Adverse events requiring (or indicated for) surgery · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether active exercise regimen changes adverse events requiring (or indicated for) surgery compared with an immobilisation regimen following surgery (very low certainty).

1 finding from 1 review

Active exercise regimen vs an immobilisation regimen following surgery

Functional assessment using a patient reported outcome measure: · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

The review found no eligible studies for this question.

2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Functional assessment using a patient reported outcome measure: · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Adverse events: participants incurring one or more adverse events · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse events: participants incurring one or more adverse events compared with early controlled passive exercise regimen (very low certainty).

1 finding from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Tendon rupture · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse event (tendon rupture) compared with early controlled passive exercise regimen (very low certainty).

1 finding from 1 review

Antioxidants vs placebo

Muscle soreness · mainly physically active individuals1 partaking in exercise2 designed to produce delayed onset muscle soreness

Summary of findings: antioxidants showed no clear difference in muscle soreness compared with placebo (low certainty).

5 findings from 1 review
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Intervention not reported

Subjective knee score ‐ KOOS‐4 score (mean score of 4 components) at 2 years: score from 0 (extreme symptoms) to 100 (no symptoms) · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)
1 finding from 1 review

Intervention not reported

Treatment failure (graft rupture or ACL reconstruction) at 2 years5 · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention may leads to lower treatment failure (graft rupture or ACL reconstruction) at 2 years5 (low certainty).

1 finding from 1 review

Intervention not reported

Treatment failure (meniscal surgery) at 5 years5,7 · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention showed no clear difference in treatment failure (meniscal surgery) at 5 years5,7 (low certainty).

1 finding from 1 review

Intervention not reported

General health‐related quality of life: SF‐36 physical component score (range 0 to 100; higher score = better health state) at 2 years · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)
1 finding from 1 review

Intervention not reported

Return to activity or level of sport at 2 years · Adults with acute anterior cruciate ligament (ACL) injuries (young, active individuals)

The intervention showed no clear difference in return to activity or level of sport at 2 years (low certainty).

1 finding from 1 review

Summary of findings: whole‐body cryotherapy (WBC) vs control (no WBC or passive rest)

Muscle pain at rest · physically‐active adults partaking in exercise designed to produce delayed onset muscle soreness (most trial participants were male)

It is very uncertain whether summary of findings: whole‐body cryotherapy (WBC) changes muscle soreness: pain at rest (VAS) compared with control (no WBC or passive rest) (very low certainty).

4 findings from 1 review
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