Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 189 findings · 18 reviews · Headline outcomes only

No studies found 28 · 14.8%GRADE not reported 17 · 9%Very low 44 · 23.3%Low 53 · 28%Moderate 44 · 23.3%High 3 · 1.6%

Ablation vs antiarrhythmic drug

Cardiac hospitalisation Hospitalisations directly related to ablation or antiarrhythmic drugs · people with non‐paroxysmal atrial fibrillation

Ablation may leads to lower cardiac hospitalisation Hospitalisations directly related to… compared with antiarrhythmic drug (low certainty).

1 finding from 1 review

Laser ablation vs radiofrequency ablation

Cancer‐related mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether laser ablation changes cancer‐related mortality at maximal compared with radiofrequency ablation (very low certainty).

1 finding from 1 review

Laser ablation vs radiofrequency ablation

Serious adverse events (number of participants) · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether laser ablation changes serious adverse events (number of participants) compared with radiofrequency ablation (very low certainty).

1 finding from 1 review

Second‐generation endometrial ablation vs first‐generation endometrial ablation

Proportion given local anaesthesia (%) · heavy menstrual bleeding

It is very uncertain whether overall analyses: second‐generation endometrial ablation changes proportion given local anaesthesia (%) compared with first‐generation endometrial ablation (very low certainty).

1 finding from 1 review