What do systematic reviews say?

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

Pain‐free response at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

Pain‐free response at 2 h for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

Headache relief at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

Sustained pain‐free during the 24 h post dose for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

Sustained pain‐free during the 24 h post dose for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain