Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,938 questions · 2,020 findings · 107 reviews

No studies found 570 · 28.2%GRADE not reported 266 · 13.2%Very low 578 · 28.6%Low 462 · 22.9%Moderate 118 · 5.8%High 26 · 1.3%

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Pain on TMJ palpation (ordinal scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain on TMJ palpation (ordinal scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral gabapentin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral diazepam vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral propranolol vs placebo

Change in pain index · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) showed no clear difference in change in pain index compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Participants' assessment of improvement of pain in right TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in participants' assessment of improvement of pain in right TMJ (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral prazepam (benzodiazepine) vs placebo

No improvement in TMJ pain on external palpation · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in TMJ pain on external palpation compared with placebo; GRADE not reported.

2 findings from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of right masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of right masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral prazepam (benzodiazepine) vs placebo

No improvement in spontaneous TMJ pain · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in spontaneous TMJ pain compared with placebo; GRADE not reported.

2 findings from 1 review

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous masseter muscle pain (numerical graph rating scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous masseter muscle pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous TMJ pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Total pain rating index (McGill Pain Questionnaire) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in total pain rating index (McGill Pain Questionnaire) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral prazepam (benzodiazepine) vs placebo

No improvement in TMJ pain during mastication · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in TMJ pain during mastication compared with placebo; GRADE not reported.

2 findings from 1 review

Oral gabapentin vs placebo

Participants' assessment of global function (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) showed no clear difference in participants' assessment of global function (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review