Findings

What do systematic reviews say?

4,749 questions · 17,858 findings · 1,266 reviews

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No studies found 4,359 · 24.4%GRADE not reported 2,348 · 13.1%Very low 4,634 · 25.9%Low 4,000 · 22.4%Moderate 2,052 · 11.5%High 465 · 2.6%

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Intervention not reported

Duloxetine high dose RCTs: 10 Participants: 4000 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
10 participants
Very low

Intervention not reported

Duloxetine low dose RCTs: 6 Participants: 1031 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 participants
Very low

Intervention not reported

Milnacipran high dose RCTs: 7 Participants: 2837 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
7 participants
Very low

Intervention not reported

Amitriptyline standard dose RCTs: 10 Participants: 997 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
10 participants
Very low

Intervention not reported

Duloxetine high dose RCTs: 14 Participants: 3692 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
14 participants
Moderate

Intervention not reported

Esreboxetine standard dose RCTs: 1 Participants: 783 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Very low

Intervention not reported

Milnacipran high dose RCTs: 1 Participants: 384 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Very low

Intervention not reported

Esreboxetine standard dose RCTs: 1 Participants: 828 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Low

Intervention not reported

Milnacipran standard dose RCTs: 2 Participants: 1298 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 participants
Low

Intervention not reported

Mirtazapine standard dose RCTs: 1 Participants: 422 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Low

Intervention not reported

Duloxetine low dose RCTs: 6 Participants: 1116 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 participants
Moderate

Intervention not reported

Esreboxetine high dose RCTs: 1 Participants: 555 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

1 finding from 1 review

Antidepressants for pain management in adults with chronic pain: a network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Very low

Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs placebo or control

Pain (PIPP) · neonates

3 findings from 1 review

Sucrose analgesia for heel‐lance procedures in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 547 participants
Moderate
Sucrose analgesia for heel‐lance procedures in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 227 participants
Low
Sucrose analgesia for heel‐lance procedures in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 164 participants
Moderate

Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs placebo or control

PIPP ‐ Preterm infants · neonates

1 finding from 1 review

Sucrose analgesia for heel‐lance procedures in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 192 participants
Low

Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs placebo or control

DAN scores at 30 seconds after heel lancing (term infants)Scale from: 0 to 10 · neonates

1 finding from 1 review

Sucrose analgesia for heel‐lance procedures in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs placebo or control

Neonatal Infant Pain Scale (NIPS) · neonates

1 finding from 1 review

Sucrose analgesia for heel‐lance procedures in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Moderate

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 119 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Physical function · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 182 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Disease activity · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 184 participants
Moderate

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Participant‐reported pain intensity VAS (0‐10, lower score = less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 121 participants
Low