Cochrane · systematic review · CD014806
Sucrose analgesia for heel‐lance procedures in neonates
Yamada, J, Bueno, M, Santos, L, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
28
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 12 · 42.9%Low 13 · 46.4%Moderate 3 · 10.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) compared to control (water, placebo, or no intervention) for analgesia for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP scores at 30 seconds after lancing (term and preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs control (water, placebo, or no intervention) | no estimate extracted | 7 studies · 547 participants | Moderate Downgraded: inconsistency |
PIPP scores at 30 seconds after heel lancing (term infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs control (water, placebo, or no intervention) | no estimate extracted | 3 studies · 227 participants | Low Downgraded: imprecision, inconsistency |
PIPP scores at 30 seconds after lancing (preterm infants)Scale from: 0 to 18 Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs control (water, placebo, or no intervention) | no estimate extracted | 3 studies · 192 participants | Low Downgraded: inconsistency |
PIPP scores at 60 seconds after lancing (preterm and term infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs control (water, placebo, or no intervention) | no estimate extracted | 2 studies · 164 participants | Moderate Downgraded: imprecision |
DAN scores at 30 seconds after heel lancing (term infants)Scale from: 0 to 10 Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs control (water, placebo, or no intervention) | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
NIPS scores immediately after heel lance (term infants)Scale from: 0 to 7i,j Summary of findings table ‐ Sucrose (any concentration, any dose, with or without NNS) vs control (water, placebo, or no intervention) | no estimate extracted | 1 study · 56 participants | Moderate Downgraded: imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to NNS for analgesia for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP scores during recovery after heel lancing (preterm infants)Scale from: 0 to 21a,b Summary of findings table ‐ Sucrose (any concentration, any dose) vs NNS | no estimate extracted | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision |
DAN scores at 30 seconds after heel lancing (term infants)Scale from: 0 to 10 Summary of findings table ‐ Sucrose (any concentration, any dose) vs NNS | no estimate extracted | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) + NNS compared to NNS (with or without water) for analgesia for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP scores during heel lancing (preterm infants)Scale from: 0 to 21a,b Summary of findings table ‐ Sucrose (any concentration, any dose) + NNS vs NNS (with or without water) | no estimate extracted | 1 study · 44 participants | Very low Downgraded: risk of bias, imprecision |
PIPP scores during recovery after heel lancing (preterm infants)Scale from: 0 to 21a,e Summary of findings table ‐ Sucrose (any concentration, any dose) + NNS vs NNS (with or without water) | no estimate extracted | 1 study · 44 participants | Very low Downgraded: risk of bias, imprecision |
NFCS during heel lancing (term infants)Scale from: 0 to 9f,g Summary of findings table ‐ Sucrose (any concentration, any dose) + NNS vs NNS (with or without water) | no estimate extracted | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to glucose (any concentration, any dose) for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP scores at 30 seconds after heel lancing (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs glucose (any concentration, any dose) | no estimate extracted | 1 study · 94 participants | Low Downgraded: risk of bias, imprecision |
PIPP scores at 60 seconds after heel lancing (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs glucose (any concentration, any dose) | no estimate extracted | 1 study · 94 participants | Low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to breastfeeding for analgesia for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP scores at 30 seconds after heel lancing (term and preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs breastfeeding | no estimate extracted | 2 studies · 148 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
COMFORTneo scores after heel lancing (preterm infants)Scale from: 6 to 30e Summary of findings table ‐ Sucrose (any concentration, any dose) vs breastfeeding | no estimate extracted | 1 study · 47 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to expressed breast milk for analgesia for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP‐R scores during heel lancing (preterm infants)Scale from: 0 to 21a,b Summary of findings table ‐ Sucrose (any concentration, any dose) vs expressed breast milk | no estimate extracted | 1 study · 88 participants | Low Downgraded: risk of bias, imprecision |
PIPP‐R scores at 30 seconds after heel lancing (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs expressed breast milk | no estimate extracted | 1 study · 88 participants | Low Downgraded: risk of bias, imprecision |
PIPP‐R scores at 60 seconds after heel lancing (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs expressed breast milk | no estimate extracted | 1 study · 88 participants | Low Downgraded: risk of bias, imprecision |
DAN scores at 30 seconds after heel lancing (term infants)Scale from: 0 to 10 Summary of findings table ‐ Sucrose (any concentration, any dose) vs expressed breast milk | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to laser acupuncture for analgesia for heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
NIPS scores during heel lancing (term infants)Scale from: 0 to 7a,b Summary of findings table ‐ Sucrose (any concentration, any dose) vs laser acupuncture | no estimate extracted | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to facilitated tucking for analgesia during repeated heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BPSN scores during heel lancing (preterm infants)Scale from: 0 to 27a,b Summary of findings table ‐ Sucrose (any concentration, any dose) vs facilitated tucking | no estimate extracted | 1 study · 48 participants | Very low Downgraded: risk of bias, imprecision |
BPSN scores during recovery after heel lancing (preterm infants)Scale from: 0 to 27a,e Summary of findings table ‐ Sucrose (any concentration, any dose) vs facilitated tucking | no estimate extracted | 1 study · 48 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Sucrose (any concentration, any dose) compared to skin to skin care + water for analgesia during repeated heel lancing in neonates
Population: neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP scores at 30 seconds after heel lancing ‐ Lancing #1 (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs skin to skin care + water | no estimate extracted | 1 study · 151 participants | Low Downgraded: risk of bias, imprecision |
PIPP scores at 30 seconds after heel lancing ‐ Lancing #2 (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs skin to skin care + water | no estimate extracted | 1 study · 144 participants | Low Downgraded: risk of bias, imprecision |
PIPP scores at 30 seconds after heel lancing ‐ Lancing #3 (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs skin to skin care + water | no estimate extracted | 1 study · 111 participants | Low Downgraded: risk of bias, imprecision |
PIPP scores at 60 seconds after heel lancing ‐ Lancing #1 (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs skin to skin care + water | no estimate extracted | 1 study · 154 participants | Low Downgraded: risk of bias, imprecision |
PIPP scores at 60 seconds after heel lancing ‐ Lancing #2 (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs skin to skin care + water | no estimate extracted | 1 study · 143 participants | Low Downgraded: risk of bias, imprecision |
PIPP scores at 60 seconds after heel lancing ‐ Lancing #3 (preterm infants)Scale from: 0 to 21 Summary of findings table ‐ Sucrose (any concentration, any dose) vs skin to skin care + water | no estimate extracted | 1 study · 111 participants | Low Downgraded: risk of bias, imprecision |