Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

NSAIDs vs placebo

Annual rate of change in % predicted FVC All participants · adults and children with cystic fibrosis

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 226 participants
Moderate

NSAIDs vs placebo

Annual rate of change in % predicted FVC Subgroup: Under 13 years of age · adults and children with cystic fibrosis

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 147 participants
Moderate

NSAIDs vs placebo

Annual rate of change in % predicted FVC Subgroup: Over 13 years of age · adults and children with cystic fibrosis

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 79 participants
Moderate

NSAIDs vs placebo

Transmission‐related outcomes: hospitalization ‐ Number or proportion of hospital admissions · adults and children with cystic fibrosis

Summary of findings: non‐steroidal anti‐inflammatory drugs showed no clear difference in proportion with at least 1 hospital admission compared with placebo (moderate certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
OR 0.61 [0.37, 1.01]
4 studies · 286 participants
Moderate

Inhaled corticosteroids vs placebo

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 250 participants
Low

Inhaled corticosteroids vs placebo

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 250 participants
Low

Inhaled corticosteroids vs placebo

BHR: change in PC20 values · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 100 participants
Very low

Inhaled corticosteroids vs placebo

Change in exercise tolerance · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Inhaled corticosteroids vs placebo

Respiratory exacerbations: number of days on intravenous antibiotics for respiratory exacerbations · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: inhaled corticosteroids changes respiratory exacerbations: number of days on intravenous antibiotics… compared with placebo (very low certainty).

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Inhaled corticosteroids vs placebo

Quality of life: Quality of Well Being score change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Inhaled corticosteroids vs placebo

Adverse effects · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 295 participants
Low

Intervention not reported

Lung function Mean percentage change in FEV1 · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 289 participants
Moderate

Intervention not reported

Lung function Mean percentage change in FVC (% predicted) · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 70 participants
Low

Intervention not reported

Nutritional status BMI · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Low

Intervention not reported

Time to first exacerbation requiring intravenous antibiotics · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 113 participants
Moderate

Intervention not reported

Antibiotic resistance patterns following treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range · adults and children with cystic fibrosis

The intervention showed no clear difference in ototoxicity An increase in auditory threshold of 20 dB or more over… (low certainty).

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
RR 0.56 [0.04, 7.96]
3 studies · 266 participants
Low

Intervention not reported

Nephrotoxicity The percentage change in creatinine over baseline · adults and children with cystic fibrosis

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 245 participants
Moderate

Summary of findings ‐ PEP vs PDPV

FEV1 % predicted: absolute change from baseline · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 155 participants
Low

Summary of findings ‐ PEP vs oscillating PEP

Direct measures of mucus clearance · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found