Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,227 questions · 2,562 findings · 156 reviews · All outcomes

No studies found 297 · 11.6%GRADE not reported 1,616 · 63.1%Very low 405 · 15.8%Low 144 · 5.6%Moderate 81 · 3.2%High 19 · 0.7%

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Lactobacilli presence (CFU > 10^5) · Adults undergoing orthodontic treatment

Aligners probably lower the risk of high lactobacilli counts versus fixed appliances in adults at 3 months (RR 0.09, 95% CI 0.02 to 0.47; low certainty).

2 findings from 1 review

Molar-incisor hypomineralisation (MIH) assessment vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

MIH prevalence · School-aged children in the United Arab Emirates (Dubai)

MIH prevalence among school-aged children in Dubai ranged from 7.6% to 27.2% across two studies, higher in females and low-socioeconomic-class schools (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Average fluorescence loss (dF%) · Adults undergoing orthodontic treatment

A single study reported lower average fluorescence (mineral) loss with aligners versus fixed appliances in adults at 3 months (MD -1.40, 95% CI -2.15 to -0.65; ungraded).

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Plaque · Adolescents/teenagers undergoing orthodontic treatment

A single study reported a lower full-mouth plaque score with aligners versus fixed appliances in adolescents at 12 months (MD -43.48, 95% CI -47.65 to -39.31; ungraded).

3 findings from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Gingival index (GI) · Adolescents/teenagers undergoing orthodontic treatment

A single study reported lower gingival index with aligners versus fixed appliances in adolescents at 18 months (MD -0.57, 95% CI -0.93 to -0.21; ungraded).

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Periodontitis (prevalence) · Adults (general and hospital populations assessed in case-control studies)

Periodontitis prevalence is significantly higher in systemic sclerosis patients than controls (OR 7.01); certainty ungraded.

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

S. mutans presence (CFU > 10^5) · Adults undergoing orthodontic treatment

Aligners probably lower the risk of high S. mutans counts versus fixed appliances in adults at 3 months (RR 0.07, 95% CI 0.01 to 0.49; low certainty).

2 findings from 1 review

COE with light-based detection (e.g. ViziLite Plus, Microlux/DL, VELscope, Identafi 3000) vs COE with vital rinsing (toluidine blue/tolonium chloride)

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Gingival index (GI) · Adults undergoing orthodontic treatment

A single study found no significant difference in gingival index between aligners and fixed appliances in adults at 6-12 weeks (MD -0.10, 95% CI -0.35 to 0.15; ungraded).

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Mean number of decayed teeth (mean DT) · Adults (general and hospital populations assessed in case-control studies)

Systemic sclerosis patients have a significantly higher number of decayed teeth than controls (SMD 0.19); certainty ungraded.

1 finding from 1 review