Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,327 questions · 2,494 findings · 87 reviews · All outcomes

No studies found 450 · 18%GRADE not reported 1,487 · 59.6%Very low 385 · 15.4%Low 121 · 4.9%Moderate 50 · 2%High 1 · 0%

Glucosamine sulfate (oral) vs ibuprofen

Pain during function (proportion without significant improvement) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) led to lower pain during function (proportion without significant improvement) compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review
  • Six participants in the glucosamine group did not experience significant improvement in TMJ pain compared with seven in the ibuprofen group (Analysis 3.1); Fisher's exact test P = 0.73 (not significant, per the authors).
    1 study · 45 participants
    GRADE not reported

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Pain reduction (VAS 0-100) · People with erosive oral lichen planus

Clobetasol-17-propionate 0.025% lipid-loaded microspheres led to lower pain reduction (VAS 0-100) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.

1 finding from 1 review

RDP with I-bar clasps / mesial rests vs RDP with circumferential clasps / distal rests

Treatment success rate · Partially edentulous patients treated with a removable dental prosthesis (RDP)

RDP with I-bar clasps / mesial rests showed no clear difference in treatment success (5-year) compared with RDP with circumferential clasps / distal rests; GRADE not reported.

1 finding from 1 review

Indigo wood root vs saline placebo

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Indigo wood root showed no clear difference in oral mucositis (moderate to severe) compared with saline (placebo); GRADE not reported.

1 finding from 1 review

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Weight (kg) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Breastfeeding (post cleft-lip surgery) led to higher weight (kg) compared with spoon-feeding; GRADE not reported.

1 finding from 1 review

Maternal advice and support (feeding techniques/breastfeeding positions) vs Usual care (no additional advice/support)

Outcome not reported · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy vs Placebo or no active treatment

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Laser (low level) showed no clear difference in oral mucositis (any severity) compared with placebo/sham/no treatment; GRADE not reported.

1 finding from 1 review

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Length of hospital stay · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Energy and protein intake · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review