Question · asked by 1 review
Glucosamine sulfate (oral) vs ibuprofen: Pain during function (proportion without significant improvement)
- Population
- Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria
- Intervention
- Glucosamine sulfate (oral)
- Comparison
- ibuprofen
- Outcome
- Pain during function (proportion without significant improvement)
Glucosamine sulfate (oral) led to lower pain during function (proportion without significant improvement) compared with ibuprofen (oral); GRADE not reported.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Glucosamine sulfate (oral) vs Ibuprofen (oral) Pain during function (proportion without significant improvement) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria · 90 days Glucosamine sulfate (oral) led to lower pain during function (proportion without significant improvement) compared with ibuprofen (oral); GRADE not reported. Interventions for managing temporomandibular joint osteoarthritis (2012) · Cochrane All outcomes | Six participants in the glucosamine group did not experience significant improvement in TMJ pain compared with seven in the ibuprofen group (Analysis 3.1); Fisher's exact test P = 0.73 (not significant, per the authors). | 1 study · 45 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes | 2011-09 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.