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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Toothbrushing + 0.075% cetylpyridinium chloride mouthwash vs Toothbrushing alone

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Toothbrushing + 0.075% cetylpyridinium chloride mouthwash may leads to lower dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with toothbrushing (low certainty).

1 finding from 1 review

0.6% eucalyptus chewing gum vs Placebo chewing gum

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether 0.6% eucalyptus chewing gum changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo chewing gum (very low certainty).

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
1 finding from 1 review
  • Antibiotic use for irreversible pulpitis 2019 · Cochrane All outcomes
    7 days
    Corresponding risk (Antibiotics): The in between-group differences (median +/- IQR) in SPID for the penicillin group were 6.0 +/- 10.5, and for placebo 6.0 +/- 9.5. The SPPID for the penicillin group was 3.5 +/- 7.5…
    1 study · 40 participants
    Low

Electric toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

Gingival inflammation (medium term) · Children and adults with mixed levels of ID; setting home, residential, day care, school, mixed or not specified

Electric toothbrush (self, carer or carer-assisted brushing) showed no clear difference in gingival inflammation (medium term) compared with manual toothbrush (self, carer or carer-assisted brushing) (moderate certainty).

1 finding from 1 review

Acupuncture at P6 point with sedation vs Sham (dummy) acupuncture with sedation

Completion of dental treatment · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupuncture at P6 point with sedation changes completion of dental procedure compared with sham (dummy) acupuncture with sedation (very low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), patient-reported (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… led to lower postoperative hypersensitivity (POH), patient-reported (VAS score) compared with no liner (resin-based composite bonded directly to the tooth); GRADE not reported.

2 findings from 1 review

Special manual toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

Oral health assessment and oral bacteria levels (medium term) · Children and adults with mixed levels of ID; setting home, residential, day care, school, mixed or not specified
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Medium term (6 weeks to 12 months)
    Comparison 1.5 (graded in the Effects of interventions text; not tabulated in the SoF). Single-use suction toothbrush vs standard manual toothbrush (both with a chemical agent), 90 days, Ferozali 2007: Total Oral…
    1 study · 22 participants
    Very low

Salvadora persica (miswak) mouthrinse vs Chlorhexidine mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether miswak (Salvadora persica) mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with chlorhexidine mouthwash (very low certainty).

1 finding from 1 review

Acupressure at P6 point with thumb plus sedation vs Sham (dummy) acupressure with sedation

Adverse effects · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste probably leads to lower caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (moderate certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

440 to 550 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review

Oral hygiene training (toothbrushing routine) of people with ID vs No oral hygiene training of people with ID

Plaque · Children and adults with mild to profound ID; setting residential or school

It is very uncertain whether oral hygiene training (toothbrushing routine) of people with ID changes plaque (short term) compared with no oral hygiene training of people with ID (very low certainty).

1 finding from 1 review

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Composite resin for bonding brackets

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
1 finding from 1 review

1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1 finding from 1 review