Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,935 questions · 1,986 findings · 260 reviews · Headline outcomes only

No studies found 503 · 25.3%GRADE not reported 76 · 3.8%Very low 593 · 29.9%Low 509 · 25.6%Moderate 241 · 12.1%High 64 · 3.2%

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 1 week after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 1 week after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 3 months after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Recurrence after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in recurrence rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Primary outcome: Histological complete response ( available‐case analysis) No residual LM in staged excision 2 months post‐treatment · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in primary outcome: Histological complete response (intention‐to‐treat)… compared with imiquimod 5% cream alone (low certainty).

2 findings from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Discontinuation of treatment due to side effects ( · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in secondary outcome: Discontinuation of treatment because of harms… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Secondary outcome: Inflammatory response (number of lesions with grade 2 or 3) Grade 2 or 3 Inflammation² · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel may leads to higher secondary outcome: Inflammatory response (number of lesions with… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Mortality during time on waiting list (ITT) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes mortality during time on waiting list (ITT) compared with standard diet alone (very low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Six months mortality after liver transplantation (ITT) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes six months mortality after liver transplantation (ITT) compared with standard diet alone (very low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Mild acute rejection episodes (within 6 months after LTx) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes mild acute rejection episodes (within 6 months after LTx) compared with standard diet alone (very low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Severe acute rejection episodes (within six months after LTx) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes severe acute rejection episodes (within six months after LTx) compared with standard diet alone (very low certainty).

1 finding from 1 review

Intervention not reported

Knowledge and understanding Variable scales: information (amount and type) needs/preferences; discordance between patient and physician survival and curability estimates Timing: immediately to 1 month post‐consultation · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review

Intervention not reported

Evaluation of the communication: different constructs (perceptions of communication quality; patient‐centredness of communication; involvement preferences; doctor‐patient relationship measures) Timing: immediately post‐consultation to 18 weeks pos... · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review

Intervention not reported

Discussions of EoL/EoL care: discussion occurrence EMR review post‐death; coding of consultations; self‐reported occurrence Timing: immediately, 1 or 2 weeks post‐consultation; after death · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review