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Evidence found and GRADE certainty

4,734 questions · 15,288 findings · 893 reviews

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No studies found 3,864 · 25.3%GRADE not reported 2,222 · 14.5%Very low 3,868 · 25.3%Low 3,280 · 21.5%Moderate 1,676 · 11%High 378 · 2.5%

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Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke

Pharmacological intervention and non‐invasive brain stimulation… may leads to lower depression: meeting the criteria for depression at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (low certainty).

2 findings from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes depression: < 50% reduction in scale scores at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke
1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: death (secondary outcome) compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ central nervous system events (e.g. headache, seizures) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ central nervous system events (e.g. headache,… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ other events ‐ not listed above (e.g. dysuria, neck pain, eye discomfort) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ other events ‐ not listed above (e.g.… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation vs usual care with or without sham interventions

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether non‐invasive brain stimulation changes depression: < 50% reduction in scale scores at end of treatment… compared with sham non‐invasive brain stimulation and/or usual care (very low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Change in depression score ( · adolescents and adults with congenital heart disease
2 findings from 1 review

Surgery vs botulinum neurotoxin injections

Treatment success: improvement in the angle of strabismus at 6 months · children with infantile esotropia

It is very uncertain whether surgery changes treatment success: improvement in the angle of strabismus at 6 months compared with botulinum neurotoxin injections (very low certainty).

1 finding from 1 review

Prednisone vs placebo or supportive treatment

Any continuing kidney disease at 3 months (study with high risk of bias excluded) · patients with IgAV

Prednisone showed no clear difference in children with any continuing kidney disease at 3 months compared with placebo or supportive treatment (moderate certainty).

2 findings from 1 review

Prednisone vs placebo or supportive treatment

Any continuing kidney disease at 12 months (study with high risk of bias excluded) · patients with IgAV

Prednisone showed no clear difference in children with any continuing kidney disease at 12 months compared with placebo or supportive treatment (low certainty).

2 findings from 1 review