Question · asked by 1 review

Prednisone vs placebo or supportive treatment: Any continuing kidney disease at 12 months (study with high risk of bias excluded)

Prednisone showed no clear difference in children with any continuing kidney disease at 12 months compared with placebo or supportive treatment (low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Prednisone vs placebo or supportive treatment
Children with any continuing kidney disease at 12 months · patients with IgAV
Prednisone showed no clear difference in children with any continuing kidney disease at 12 months compared with placebo or supportive treatment (low certainty).
Interventions for preventing and treating kidney disease in IgA vasculitis (2023) · Cochrane Headline outcomes only
RR 1.06 [0.38, 2.91]3 studies · 455 participantsLow
Prednisone vs placebo or supportive treatment
Any continuing kidney disease at 12 months (study with high risk of bias excluded) · patients with IgAV
Prednisone showed no clear difference in any continuing kidney disease at 12 months (study with high risk of… compared with placebo or supportive treatment (moderate certainty).
Interventions for preventing and treating kidney disease in IgA vasculitis (2023) · Cochrane Headline outcomes only
RR 1.39 [0.75, 2.59]2 studies · 287 participantsModerate

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Interventions for preventing and treating kidney disease in IgA vasculitis
2023 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.