Adverse events: all grades · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma showed no clear difference in adverse events of any grade up to 28 days (data only available for… compared with saline placebo (low certainty).
1 finding from 1 review
RR 0.98 [0.81, 1.18]
Studies not reported
Low
Grades 3 and 4 adverse events · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma probably leads to higher adverse events at grades 3 to 4 up to 28 days compared with saline placebo (moderate certainty).
1 finding from 1 review
RR 4.09 [1.39, 12.01]
Studies not reported
Moderate
Serious adverse events up to day 28 (data available only as a composite of serious adverse events or death up to day 28) · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma showed no clear difference in serious adverse events up to day 28 (data available only as a… compared with saline placebo (low certainty).
1 finding from 1 review
RR 0.72 [0.45, 1.14]
Studies not reported
Low
All‐cause mortality (by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in all‐cause mortality (by day 28) compared with saline placebo (low certainty).
1 finding from 1 review
Worsening of clinical status (expressed as new need for IMV, admission to ICU, or death by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in worsening of clinical status (expressed as new need for IMV,… compared with saline placebo (low certainty).
1 finding from 1 review
Improvement in vertigo frequency · Ménière’s disease
It is very uncertain whether betahistine changes improvement in vertigo frequency compared with placebo/no treatment (very low certainty).
2 findings from 1 review
Vertigo (global score) at < 3 months · Ménière’s disease
1 finding from 1 review
Change in vertigo frequency · Ménière’s disease
2 findings from 1 review
Serious adverse events · Ménière’s disease
It is very uncertain whether betahistine changes serious adverse events compared with placebo/no treatment (very low certainty).
1 finding from 1 review
Improvement in vertigo frequency · Ménière’s disease
It is very uncertain whether diuretic changes improvement in vertigo frequency compared with placebo/no treatment (very low certainty).
1 finding from 1 review
Change in vertigo frequency · Ménière’s disease
1 finding from 1 review
NFCS pain score during the procedure№ of infants: 112(2 RCTs) Score · procedural pain in neonates
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Pain score assessed up to 10 minutes after the procedure · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Episodes of bradycardia · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Episodes of apnea · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypotension requiring medical therapy (vasopressors or fluid boluses), occurring during the procedure · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Improvement in vertigo · people with vestibular migraine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in vertigo frequency · people with vestibular migraine
1 finding from 1 review
Serious adverse events · people with vestibular migraine
It is very uncertain whether beta‐blockers changes serious adverse events compared with placebo (very low certainty).
1 finding from 1 review
Improvement in vertigo · adults with PPPD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found