Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,121 questions · 2,186 findings · 242 reviews

No studies found 493 · 22.6%GRADE not reported 158 · 7.2%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.7%High 97 · 4.4%

Intervention not reported

Hearing loss · children and adults with acute bacterial meningitis

The intervention probably leads to lower hearing loss (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: nausea, vomiting, diarrhoea · children and adults with acute bacterial meningitis

It is very uncertain whether the intervention changes adverse effects: nausea, vomiting, diarrhoea (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: gastrointestinal bleeding · children and adults with acute bacterial meningitis

The intervention showed no clear difference in adverse effects: gastrointestinal bleeding (moderate certainty).

1 finding from 1 review

Intramuscular ceftriaxone vs oral amoxicillin plus oral probenecid

Cure of gonococcal infection (microbiological culture) · pregnant women with gonorrhoea infection

It is very uncertain whether intramuscular ceftriaxone changes cure of gonococcal infection (microbiological culture) compared with oral amoxicillin plus oral probenecid (very low certainty).

1 finding from 1 review

Intramuscular ceftriaxone vs oral amoxicillin plus oral probenecid

Adverse events including treatment‐related adverse events · pregnant women with gonorrhoea infection

It is very uncertain whether intramuscular ceftriaxone changes adverse events including treatment‐related adverse events compared with oral amoxicillin plus oral probenecid (very low certainty).

1 finding from 1 review

Intramuscular ceftriaxone vs oral cefixime

Cure of gonococcal infection (microbiological culture) · pregnant women with gonorrhoea infection

It is very uncertain whether intramuscular ceftriaxone changes cure of gonococcal infection (microbiological culture) compared with oral cefixime (very low certainty).

1 finding from 1 review

Macrolides vs placebo

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides probably leads to lower ≥ 1 exacerbation compared with placebo (moderate certainty).

1 finding from 1 review

Macrolides vs placebo

Exacerbation frequency · children with bronchiectasis

Macrolides may leads to lower exacerbation frequency compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Hospitalisation (any cause) · children with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all‐cause compared with placebo (low certainty).

1 finding from 1 review