Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 473 findings · 36 reviews · HIV/AIDS

No studies found 38 · 8%GRADE not reported 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission or death at 6 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 6 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission or death at 28 weeks among those whose diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Infants with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infants with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… may leads to higher mothers with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP regimen administered to infants for 14 weeks changes infants with Probably Related Severe Adverse Events11 compared with sdNVP plus ZDV (1week) (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Virologic failure 2 successive HIV‐1 RNA >= 200copies/ml at 16+ weeks after randomisation · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in virologic failure 2 successive HIV‐1 RNA >= 200copies/ml at 16+… compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Virologic suppression Viral load < 50 copies/ml · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in virologic suppression Viral load < 50 copies/ml compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Severe adverse events · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in severe adverse events compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Hypersensitivity · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in hypersensitivity reactions compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review