An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants: HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth
- Population
- HIV‐infected mothers and their breastfeeding infants
- Intervention
- An extended antiretroviral regimen administered to mothers for 28 weeks
- Comparison
- an extended NVP regimen administered to infants
- Outcome
- HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth
An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | RR 1.78 [0.88, 3.59] | 1 study · 1618 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis · HIV‐infected mothers and their breastfeeding infants · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.