Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

303 questions · 322 findings · 45 reviews

No studies found 31 · 9.6%GRADE not reported 22 · 6.8%Very low 99 · 30.7%Low 95 · 29.5%Moderate 68 · 21.1%High 7 · 2.2%

Intervention not reported

Incidence of a secondary primary breast cancer (e.g. in the contralateral breast) ‐ endocrine therapies not separated (exemestane (AI)/tamoxifen (SERM)/unknown) · women receiving endocrine therapy (selective oestrogen receptor modulator or aromatase inhibitor)
1 finding from 1 review

Sealing using sealant materials vs Non-selective carious tissue removal and conventional restoration (CR)

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review

Sealing using sealant materials vs Non-selective carious tissue removal and conventional restoration (CR)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether sealing using sealant materials changes failure of therapy compared with non-selective carious tissue removal and conventional restoration (CR) (very low certainty).

1 finding from 1 review

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Hyperkalaemia · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in hyperkalaemia compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Death · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in death compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review